International Review of Ophthalmology ›› 2021, Vol. 45 ›› Issue (6): 529-534.doi: 10.3760/ cma.j.issn.1673-5803.2021.06.012

Previous Articles     Next Articles

Research on the mechanism of lenticular senescence

Fu Yushan,  Zhou Nan,  Qi Yanhua   

  1. Department of Ophthalmology,  the Second Affiliated Hospital,  Harbin Medical University,  Harbin 150086,  China

  • Received:2021-03-16 Online:2021-12-22 Published:2021-12-22
  • Contact: Qi Yanhua, Email: qyh86605643@126.com

Abstract:

Lens epithelium is the center of lens metabolism,  and its senescence will lead to cataract. Several mechanisms are involved in the progression of cataract including: shortening of telomere length in lens epithelial cells,  the long-term existence of intracellular oxidative stress activating multiple inflammatory pathways involved in cell signaling,  decreased autophagy activity,  and the inactivation of the anti-aging enzyme -SIRT. Meanwhile,  the damage of protein and lipid homeostasis in lens and the imbalance of water balance will accelerate the process of lens aging. (Int Rev Ophthalmol,  2021,  45: 529-534)

Key words: cataract, lens epithelial cells, lenticular senescence

CLC Number: